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Cardiovascular Disease - Desmin ( IRM006 ) cTnI ( IR294-967 ) cTnT ( IR293-964 )
Desmin, the intermediate filament protein in striated muscle, is an essential component of the striated muscle cell cytoskeleton. In muscle, the cytoskeleton is a multifunctional, dynamic, and complex structure that serves as a scaffold to maintain the structural integrity and architecture of the cardiomyocyte. However, it serves more than a passive, structural purpose as the cytoskeleton functions as a platform for inter- and intracellular signaling, linking the contractile apparatus so that sarcomeres may function efficiently as a syncytium, and linking those structures in turn to the sarcolemma, cell–cell junctions, the mitochondria, and nucleus. It is not surprising then that mutations in the gene encoding desmin can cause myopathies in general and cardiomyopathy in particular.
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Fibrocytes, CAFs and Extracellular matrix (ECM) in the Progression of Cancer
In biology, the extracellular matrix (ECM) is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
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Selectins : Trafficking of immune system cells ( IR306-909 L-selectin IR307-912 P-selectin IR308-917 E-selectin )
Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health consequences, with recurrent bacterial infections and persistent disease occurring.
During inflammation, selectins enable the initial attachment of leukocytes from the bloodstream, which causes their downstream movement along the endothelium via adhesive interactions referred to as leukocyte rolling.
Three type-I-cell surface glycoproteins make up the selectin family, namely L-selectin, P-selectin and E-selectin. L-selectin is the smallest of the selectins and is expressed on all granulocytes and monocytes and the majority of lymphocytes. P-selectin is the largest selectin and is found on the surface of activated endothelial cells and platelets. The expression of E-selectin does not occur under baseline conditions, aside from in skin microvessels, but its expression on activated endothelium is induced by inflammatory cytokines.
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Neurodegenerative Alzheimer's disease (AD) disease
Neurodegenerative diseases of the central nervous system (CNS) are characterized by progressive neuronal death and neurological dysfunction, leading to increased disability and a loss of cognitive or motor functions. Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have neurodegeneration as a primary feature.
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Fibronectin : FFPE Tissue patterns in human hepatocellular carcinoma ( HCC ) IR48-138 Fibronectin antibody
Fibronectin, a high molecular weight glycoprotein component of the extracellular matrix, was localized extracellularly and intracellularly in the nuclei and the cytoplasm of hepatocellular carcinomas (HCC). Nuclear fibronectin may be an expression of the DNA binding ability of fibronectin which becomes demonstrable in cells with increased membrane permeability.
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CD142 / coagulation factor III / tissue factor / F3 : Hemostasis in health and disease ( IR295-1, IR295-2 Tissue Factor / CD142 antibody ) )
CD142, coagulation factor III, tissue factor, F3. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under pro-coagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality.
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FNDC5 / irisin : a novel player in metabolic syndrome ( IRCP011 FNDC5 / irisin antibody )
Membrane protein fibronectin type III domain-containing protein 5 (FNDC5). The FNDC5 is cleaved and secretes irisin. Irisin enters in the blood circulation and participates in the metabolic regulation.
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IRV006 / IRV007 Influenza A / Influenza B virus Nucleoprotein (NP) Antibody
- IRV006 Anti Influenza A Virus Nucleoprotein antibody
- IRV007 Anti Influenza B Virus Nucleoprotein antibody
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Organelles Marker Antibody Sampler
Cellular components are organized into membrane-bound compartments called organelles. Organelle-specific proteins can function as markers to identify organelles in cell biology immunoassays, as well as act as a tool to explore the subcellular localization of novel proteins. iReal Biotechnology offers validated antibodies for various organelle markers.
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Better Choice for iReal Clinical-IHC antibody
Upgrade to iReal-Antibody, Achieve more sensitivity and specific IHC experimental results in your colorectal cancer study.
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ISO 13485 & CITED ANTIBODIES
Irealbio provides products supported by a quality management system that is certified for ISO 13485:2016, as well as through citation in many scientific publications.
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INB-IReal Biomarker Analyzer for Clinical Research and Diagnostics
Instant NanoBiosensors Click here
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Epithelial barrier-depend on the junctional complexes (IR57-193 Occludin / OCLN, IR56-184 ZO-1 IR55-180 E-cadherin IR49-149 beta-catenin)
The formation and effectiveness of the epithelial barrier depend on the junctional complexes, including tight junction s (TJs), adherence junctions (AJs)
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Link between ZEB1 and CD44s in EMT Program (IR53-167 ZEB1, IR208-752 CD44)
Transcription factor ZEB1, promoting tumor‐initiating capacity correlated with increased expression of the putative stem cell marker CD44.
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ER stress sensors ( CHOP, PERK, ATF6, IRE1, eIF2a, NRF2 )
Each antibody in the ER Stress-induced Antibodies detects endogenous levels of its target protein.
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IR55-180 E-cadherin antibody (Intracellular domain)
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
MW (kDa): 130-135
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IR55-179 E-cadherin antibody (Extracellular domain)
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human
MW (kDa): 130-135
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IR49-149 Beta Catenin antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR50-154 SNAIL antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse
Package : 100 μl, 25 μl
MW (kDa): 29
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IR47-146 α Smooth Muscle Actin antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 43
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IR46-143 N-cadherin antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR45-137 Vimentin antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR218-1 EpCAM antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR56-184 ZO-1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR48-147 Fibronectin / FN antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
Blocking : 3%BSA
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p63 : Squamous, Basal & Myoepithelial Cell Marker ( IR205-742 p63 antibody )
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 72-80
App : WB, ICC/IF, IHC
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IR222-861 Pan-Cytokeratin, Pan CK antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
MW (kDa): 43-55
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IR208-752 CD44 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR238-892 Cytokeratin 20 / CK20 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR228-868 Cytokeratin 7 / CK7 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR236-890 Cytokeratin 18/19, CK18/19 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR235-880 Cytokeratin 14/17, CK14/17 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR226-865 Cytokeratin 5/6, CK5/6 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR215-787 Progesterone Receptor / PR antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
MW (kDa): 90, 120
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IR213-777 Estrogen Receptor alpha / ER alpha antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 66-60
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IR219-807 c-MET antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
MW (kDa): 130-170, 40
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IR210-763 HER2 / ERBB2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
MW (kDa): 180-185
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IR211-769 EGFR
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 120-180
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IR212-772 Ki-67 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR84-366 LC3B antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR77-264 / IR77-263 CD45 antibody (Leukocyte Marker)
Host : Rabbit
Clonality : Polyclonal
Package : 100 μl, 25 μl
MW (kDa): 170-260
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IR239-896 CD138 / Syndecan1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
MW (kDa): 180 to 280
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IR81-279 VEGF Receptor 2 / KDR / CD309 / VEGFR2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR112-457 TGF beta 1 ( TGFB1 ) antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 12, 33-60
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IR108-442 VEGF antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR113-466 HIF1 alpha antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 120
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IR117-294 Cyclin D1 / CCND1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR116-289 Cyclin B1 / CCNB1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
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IR122-312 p21 Cip1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR123-314 p27 Kip1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Humant
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR115-286 CyclinA2 / CCNA2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR109_446 COX2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR114-473 IL1 beta antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR101-420 cleaved PARP Asp214 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
Blocking : 3%BSA
MW (kDa): 89, 115
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IR105-435 Cytochrome C / CYCS antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 14
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IR95-397 Caspase 1 (p20) antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR99-409 Caspase 8 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human
Package : 100 μl, 25μl
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IR94-392 BCL2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR136-543 NRF2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
MW (kDa): 125-160
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IR127-515 IRE1 alpha / ERN1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR133-535 eIF2 alpha antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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GFAP ( Astrocyte Markers ) IR15-44 GFAP antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR13-36 AIF1 / AIF / Iba1 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
Blocking : 3%BSA
MW (kDa): 15
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IR38-119 LRRK2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR11-26 SOX2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
Blocking : 3%BSA
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IR7-21 NOTCH1 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR14-38 BDNF antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR39-123 Tau / MAPT antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR8-23 Nestin / NES antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR12-33 MAP2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR44-131 Huntingtin antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR21-57 NF-H antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
Blocking : 3%BSA
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IR43-128 Alpha Synuclein (SNCA) antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR11-31 Tuj1 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
MW (kDa): 55
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IR70-234 MMP9 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR71-245 MMP14 / MT1-MMP antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR72-249 TIMP1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
MW (kDa): 26
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IR67-227 MMP2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR66-225 MMP1 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR68-229 MMP3 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR79-272 VCAM-1 / CD106 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR76-259 CD34 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR78-268 ICAM-1 / CD54 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR75-257 CD31 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human
Package : 100 μl, 25μl
Blocking : 3%BSA
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IR58-200 FAK / PTK2 antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA
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IR60-205 Paxillin antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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IR1-2-2 Vinculin antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR5-11 Lamin B1 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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IR188-706 ERK1/2 phospho (Thr202 / Tyr204) antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
Blocking : 3%BSA or 5% milk
MW (kDa): 42/44
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IR231-856 iNOS antibody
Host : Rabbit
Clonality : Polyclonal
Reactivity : Human, Mouse, Rat
Package : 100 μl, 25 μl
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AKT1+2+3 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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ERK1+ERK2 antibody
Host :Rabbit
Clonality :Polyclonal
Reactivity :Human, Mouse, Rat
Package : 100 μl, 25μl
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Endothelial Marker Dual Antibody
Endothelial cells line the interior of all blood vessels, composing the endothelium. Endothelial cells provide many essential functions, endothelial dysfunction leads t
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Cancer Stem Cells (CSCs) Markers (EpCAM CD133 CD44)
Cancer Stem Cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A number of cell surface markers such as CD44, CD24, and CD133 are often used to identify and enrich CSCs.
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EMT Marker Antibody Panel
EMT antibody panel (IR5001)
*Benefits
- Includes both epithelial and mesenchymal markers
- Includes the most suitable loading control
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Liquid Biopsy / CTC detection antibody
CTC , Circulating Tumor Cells
Detection Antibody
EpCAM CTC capturing antibody (Biotin label)
PanCK CTC detecting antibody (FITC label)
CD45 CTC detecting antibody (PE label)
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EMT marker Panel
Change of antibody signal in accordance with defined biological characteristics of target protein following specific sample. Also, analysis of signals from various cell
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MMP Remodeling Antibody Panel
MMP Remodeling antibody panel (IR5002)
*Benefits
-Drug treatment and conditional medium for MMP Biological
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IREX001 Nuclear Protein Extraction Kit
WB Image
A549 cells' cytoplasmic and nuclear proteins were extracted by 30-min.
Cytoplasmic & Nuclear Protein Extraction Kit(Cat.#IREX001).
A. SDS-PAGE gel shows the profiles of extracted cytoplasmic proteins and nuclear proteins.
B. The proteins from the gel were transferred to nitrocellulose membrane and probed with Lamin B1, Histone H3 antibody (nuclear marker) and GAPDH antibody (cytoplasmic marker).
others
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