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CAFs, role in the tumor microenvironment

Cross-talk between cancer cells and CAFs in the tumor microenvironment

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Secretion of TGF-β from cancer cells can activate fibroblasts into CAFs, increasing their contractility and expression of CAF markers, α-SMA. CAFs, in turn, secrete higher amounts of TGF-β and HGF, which further stimulate tumorigenesis, migration, invasion and metastasis of cancer cells.

Panel 1257887