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CD142 / coagulation factor III / tissue factor / F3 : Hemostasis in health and disease ( IR295-1, IR295-2 Tissue Factor / CD142 antibody ) )3
Home Products Primary antibody CD142 / coagulation factor III / tissue factor / F3 : Hemostasis in health and disease ( IR295-1, IR295-2 Tissue Factor / CD142 antibody ) )
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CD142 / coagulation factor III / tissue factor / F3 : Hemostasis in health and disease ( IR295-1, IR295-2 Tissue Factor / CD142 antibody ) )

CD142, coagulation factor III, tissue factor, F3. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII.  There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under pro-coagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality.

Catalog

Component

Clonality

Reactivity

App

IR295-1

Tissue Factor / CD142  extracellular

Rab-pAb

Human

WB, IF, IHC

IR295-2

Tissue Factor / CD142

Rab-pAb

Human

WB, IF, IHC


Overview

Product Name

Tissue Factor / CD142 extracellular antibody

Product Number

IR295-1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Recommended

Applications Dilutions

Western Blot 1:1000 - 1:2000

Immunofluorescence 1:300 – 1:600

Immunohistochemistry (Paraffin) 1:100 – 1:300

Storage Buffer

100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300

Concentration

1.5 mg/ml

Purity

Affinity column purified

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C

Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

IR295-1 anti-Tissue Factor / CD142 antibody WB image

IR295-1 anti-Tissue Factor / CD142 antibody IHC image

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Anti- Tissue Factor / CD142 antibody - at 1/1000 dilution. Lysates at 30 μg per lane. This blot was produced using a 10% SDS-PAGE. Nitrocellulose membrane was then blocked for an hour before being incubated with IR295-1 overnight at 4°C.

Immunohistochemical analysis of paraffin embedded Human cancer tissue labeling Tissue Factor / CD142 with IR295-1 at 1/100.

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