Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health consequences, with recurrent bacterial infections and persistent disease occurring. During inflammation, selectins enable the initial attachment of leukocytes from the bloodstream, which causes their downstream movement along the endothelium via adhesive interactions referred to as leukocyte rolling. Three type-I-cell surface glycoproteins make up the selectin family, namely L-selectin, P-selectin and E-selectin. L-selectin is the smallest of the selectins and is expressed on all granulocytes and monocytes and the majority of lymphocytes. P-selectin is the largest selectin and is found on the surface of activated endothelial cells and platelets. The expression of E-selectin does not occur under baseline conditions, aside from in skin microvessels, but its expression on activated endothelium is induced by inflammatory cytokines.
iReal’s GLOD CLASS antibodies for Selectin IHC experimental