Exosome
CD31
Antibodies Panel
IR99-409 anti-Caspase8 antibody WB image IR99-409 anti-Caspase8 antibody WB image IR99-409 anti-Caspase8 antibody IHC image IR99-409 anti-Caspase 8 antibody IHC image
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7
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Catalog Number:IR99-409

Caspase-8 cleaved Asp374 antibody

Application
  • WB
  • IF
  • IHC
Reactivity Hu

REACTIVITYHu
SENSITIVITYEndogenous
MW41-43, 55, 18
SOURCERabbit-IgG

Product Includes

-

Application Dilution

Western Blot 1:500 - 1:2000
Immunofluorescence 1:200 – 1:500
Immunohistochemistry (Paraffin) 1:200 – 1:300

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C
100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative

Specificity / Sensitivity

Endogenous

Source / Immunogen

Synthetic peptide / encompassing a sequence within the center region

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Title
1

Chiu, Ching-Chi et al. “(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.” Cell death & disease vol. 11,11 1018. 30 Nov. 2020

Application
  • WB
Reactivity Mouse
2

Huang, X-F et al. “Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n-butylidenephthalide in leukemia cells.” Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico vol. 23,6 (2021): 1142-1151.

Application
  • WB
Reactivity Human
3

Huang, Xiao-Fan et al. “Extract Derived from Cedrus atlantica Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo.” Molecules (Basel, Switzerland) vol. 25,20 4608. 10 Oct. 2020

Application
  • WB
Reactivity Human
4

Chien, Ju-Huei et al. “Pogostemon cablin extract as an anticancer agent on human acute myeloid leukemia.” Food science & nutrition vol. 9,6 3209-3218. 2 May. 2021

Application
  • WB
Reactivity Human
5

Chang, Wen-Tsan et al. “The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells.” Antioxidants (Basel, Switzerland) vol. 10,3 394. 5 Mar. 2021

Application
  • WB
Reactivity Human
6

Chien, Ju-Huei et al. “Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death.” International journal of medical sciences vol. 19,13 1953-1964. 31 Oct. 2022

Application
  • WB
Reactivity Human
7

Urade, Ritesh et al. “A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.” Life sciences vol. 329 (2023)

Application
  • WB
Reactivity Human

Reviews

Customer Feedback
2022-10-05 14:18:41
0
0
Customer Feedback
2022-10-05 14:18:41
0
0

Customer feedback Image
Application : Western blot
Condition / Dilution:1-1000, 3%BSA
Sample : HCT-116 drug treatment
Data from : Taipei Medical University

Customer Feedback
2022-10-05 14:17:36
0
0
Customer Feedback
2022-10-05 14:17:36
0
0

Customer feedback Image
Application : Western blot
Condition / Dilution :1-1000, 5% milk
Sample : cell drug treatment
Data from : National Chiayi University

Customer Feedback
2022-10-05 14:16:43
0
0
Customer Feedback
2022-10-05 14:16:43
0
0

Customer feedback Image
Application : Western blot
Condition / Dilution: 1-1000, 3%BSA
Sample : HCT-116 drug treatment
Data from : Taipei Medical University

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