Product Includes
Application Dilution
Immunohistochemistry (Paraffin) 1:200 – 1:400
Flow Cytometry 1:100
Storage
100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
Specificity / Sensitivity
Source / Immunogen
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
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Reviews
IR251-890 anti-CD8 antibody FACS image
Product：CD8 antibody
Catalog：IR251-890
Cell: Human peripheral blood lymphocytes
CD4 antibody: 1-100
IR251-890 anti-CD8 antibody WB image
Anti-CD4 antibody at 1/500 dilution
Lysates at 50 μg per lane. This blot was produced using a 10% SDS-PAGE. NC membrane was then blocked for an hour before being incubated with IR251-890 overnight at 4°C.