IR253-901 anti-CD19 antibody WB image IR253-901 anti-CD19 antibody FACS image IR253-901 anti-CD19 antibody ICC/IF image IR253-901 anti-CD19 antibody IHC image
Catalog Number:IR253-901

CD19 antibody

  • WB
  • IF
  • IHC
  • FC
Reactivity Hu

MW95 to 110

Product Includes


Application Dilution

Western Blot 1:500 – 1:1000
Immunofluorescence 1:300 – 1:400
Immunohistochemistry (Paraffin) 1:300 – 1:500
Flow Cytometry 1:100 – 1:200


Store at +4°C for short term storage. Long time storage is recommended at -20°C
100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative

Specificity / Sensitivity


Source / Immunogen

Synthetic peptide / Extracellular domain corresponding to Human CD19

This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]

No data.


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