SARS-Cov-2
Apoptosis
IRM001 anti-alpha Tubulin monoclonal antibody WB image IRM001 anti-alpha Tubulin monoclonal antibody ICC/IF image
Catalog Number:IRM001

Alpha tubulin monoclonal antibody

Application
  • WB
  • IF
  • ELISA
Reactivity Hu、Ms、Rat

REACTIVITYHu、Ms、Rat
SENSITIVITYEndogenous
MW50
SOURCEMouse IgG1

Product Includes

-

Application Dilution

Western Blot 1:3000-1:6000
Immunofluorescence 1:200–1:500
ELISA 1:10000-1:20000

Storage

Long time storage is recommended at -20°C. Avoid repeated freeze/thaw cycles.
50mM Tris Glycine, 40% Glycerol (pH7.4). 0.025% ProClin 300 was added as a preservative

Specificity / Sensitivity

Endogenous

Source / Immunogen

-

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Title
No data.

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