Exosome
CD31
Antibodies Panel
IR113-466 anti-HIF1 alpha antibody WB image IR113-466 anti-HIF1 alpha antibody ICC/IF image IR113-466 anti-HIF1 alpha antibody IHC image
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Catalog Number：IR113-466

HIF1 alpha antibody

Application
  • WB
  • IF
  • IHC
Reactivity Hu、Ms、Rat

REACTIVITYHu、Ms、Rat
SENSITIVITYEndogenous
MW120
SOURCERabbit-IgG

Product Includes

-

Application Dilution

Western Blot 1:500
Immunofluorescence 1:100-1:200
Immunohistochemistry (Paraffin) 1:100-1:200

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C
100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative

Specificity / Sensitivity

Endogenous

Source / Immunogen

Synthetic peptide / encompassing a sequence within the center region

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

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Title
1

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

Application
  • WB
Reactivity Human
2

Chiang, Milton D et al. “Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice.” Antioxidants (Basel, Switzerland) vol. 11,4 615. 23 Mar. 2022

Application
  • WB
Reactivity Mouse
3

Le, Van Long et al. “Therapeutic Effects of Engineered Exosomes from RAW264.7 Cells Overexpressing hsa-let-7i-5p against Sepsis in Mice-A Comparative Study with Human Placenta-Derived Mesenchymal Stem Cell Exosomes.” Journal of personalized medicine vol. 14,6 619. 9 Jun. 2024

Application
  • WB
Reactivity Mouse
4

Syu SH, Chang CY, Shih HJ, Huang CJ. Pyrroloquinoline Quinone Mitigates Testicular Injury and Reduces Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Rats with Testicular Ischemia-Reperfusion Injury. Antioxidants (Basel). 2025 Oct 31;14(11):1312.

Application
  • WB
  • IHC
Reactivity Rat
5

Reciprocal Feedback Blockade with Trametinib and Imatinib Overcomes the Limitations of Current KRAS-targeted Therapy

Application
  • WB
Reactivity Mouse
6

Chung IC, Chuang TY, Ko YT, Chen ML, Hsu PY, Huang WC, Yuan TT. Extracellular Enolase-1 Promotes CAF-Associated Stromal Reprogramming via the Plasmin/TGF-β Axis in Multiple Myeloma. Cancers (Basel). 2026 May 2;18(9):1467.

Application
  • WB
Reactivity Human

Reviews

Customer Feedback
2022-11-17 10:00:00
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0
Customer Feedback
2022-11-17 10:00:00
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0

Customer feedback Image
Application : Western blot
Condition / Dilution： 1-500
Sample : HCT-116 drug treatment
Data from : Taipei Medical University

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